HandBrake Convert ISO to MP4
Before starting HandBrake ISO to MP4, please make sure you have installed the latest version of HandBrake. If not, please download it here: https://HandBrake.fr/
Step 1. Run HandBrake and a Source Selection interface will pop up.
Step 2. Click File on the left (Open a single video file) to import your ISO image file or drag and drop the ISO file directly to the interface. HandBrake will scan the DVD ISO titles and load the contents.
However, one thing to note is that HandBrake CANNOT circumvent copy protection of any kind, it only works with DRM-free discs and ISO files. If you encounter the "No valid source or titles found." prompt when importing an ISO file, this means that the ISO file contains copy protection encryption.
Convert ISO to MKV HandBrake
Step 3. Then, select the title, preset format or devices as you wish. In the Summary tab below, select MP4 or MKV as the output format. Under the Subtitles tab, select Add ISO built-in subtitles or external subtitle. Of course, you can also customize audio and video codecs under the Video and Audio tabs.
Step 4. Select the output directory at the bottom Save As box.
Step 5. Finally, click on the green Start Encode button to start the conversion of HandBrake ISO to MP4 or HandBrake ISO to MKV.